Semaglutide Injection: What You Need to Know 2023

Semaglutide Injection: What You Need to Know!

Semaglutide injection helps control diabetes and weight loss, but it is not a cure. Keep using semaglutide injection even if you feel fine. Do not stop using semaglutide injections without first talking to your doctor.

Diabetes is a chronic condition that affects the pancreas and leads to high blood sugar. In order to regulate blood sugar, people with diabetes use insulin injections, but this doesn’t work for everyone.

Semaglutide injection is a new injectable medication specifically designed for type 2 diabetes patients who still require insulin injections, but it may be a good option for those who have trouble managing their disease with other treatments.

If you or someone you know has been diagnosed with type 2 diabetes and is using insulin injections as their primary treatment, read on to learn more about semaglutide injection.

What is Semaglutide Injection?

Semaglutide injection is a new injectable medication for type 2 diabetes patients who still require insulin injections. This new drug is a GLP-1 analogue, meaning it works by lowering blood sugar levels. It’s been shown to reduce A1c levels more effectively than the current standard of care, which is insulin injections alone.

It’s important to note that semaglutide injection isn’t a cure for type 2 diabetes and will not make insulin unnecessary. Instead, the company that makes the product, Eli Lilly and Company, recommends it be used in addition to insulin injections.

What are the Benefits?

The benefits include:

  • It is injected once a day, every day.
  • It has been shown to be safe and effective for people who still need insulin injections after trying other treatments.
  • It can be used as an additional treatment or as a replacement for insulin injections.
  • Patients reported weight loss with semaglutide injection use.
  • Improvements were seen in levels of glucose, triglycerides, and HDL cholesterol.
  • Improve glycemic control, which is the ability to control blood sugar levels through diet and exercise.

Finally, it’s not a new drug but is instead a “long-acting” form of injectable insulin that lasts for up to 24 hours after administration, so it doesn’t require daily injections like the current standard of care requires.

What are the risks?

Because semaglutide injection is being marketed specifically for type 2 diabetes patients, it’s important to note that it’s not a cure for the condition and will not make insulin injections unnecessary. In fact, it’s recommended that patients continue to use their insulin injections as well.

The side effects of semaglutide injection include:

  • It may cause low blood sugar in some patients.
  • It can cause a change in body fat distribution and affect glucose metabolism.
  • There are also risks of liver toxicity and hypoglycemia.
  • The product is currently only available through prescription, but Eli Lilly and Company hopes to make it available over the counter in the future.
  • There have been multiple cases of liver failure associated with this product, so many doctors are hesitant to use it until more research has been done on its safety.

If you or someone you know has been diagnosed with type 2 diabetes, please contact us today for more information. We’re here to help.

Who can take semaglutide injection?

Semaglutide injection is only FDA-approved for type 2 diabetes patients who still require insulin injections, but not for those who are on oral medications or have type 1 diabetes.

What are the benefits of semaglutide?

Semaglutide injection can help lower blood sugar levels by up to 50 percent in adults with type 2 diabetes. Furthermore, it has been shown to reduce body weight and LDL cholesterol levels. It also helps stabilize blood sugar levels after meals, which can eliminate the need for insulin shots during mealtimes.

What are the side effects of semaglutide?

The most common side effects of semaglutide are nausea, vomiting, headache, diarrhea, weakness, and dizziness. These symptoms tend to go away after the first month of treatment. If you experience any unusual symptoms that persist longer than one month, contact your doctor immediately.

How does it work?

Semaglutide injection is a new injectable medication that has been approved to help manage blood sugar in adults, ages 18 and over, with type 2 diabetes. It works by helping the body use insulin more effectively and slowing down the absorption of glucose in the bloodstream.

Semaglutide injection can be beneficial for people who still need insulin injections as a primary treatment. If you have type 2 diabetes and are struggling with your blood sugar levels, it may be worth discussing semaglutide injection with your doctor.

Potential side-effects and risks

Semaglutide injection may cause side effects that are similar to other diabetes treatments, but there are also some potential side effects that can be more serious.

One of the most serious possible side-effects is pancreatitis. Pancreatitis is inflammation in the pancreas and if it becomes severe, it may require hospitalization. This inflammation can also cause pancreatic cancer.

Other possible side effects include skin reactions, mouth ulcers, nausea, vomiting, diarrhea, dizziness, headache, weight loss or gain, and abdominal pain/discomfort. Unfortunately, those who have not responded well to other therapies for type 2 diabetes treatment could be at an increased risk when using semaglutide injection because it could aggravate their condition.


Semaglutide injection is a new diabetes drug that works by mimicking the effects of a hormone called GLP-1. It can be injected under the skin, making it similar to the injectable diabetes medications already on the market.

The benefits of semaglutide injection are that it can help with blood sugar control for up to 24 hours, it has no effect on blood pressure, and it does not cause weight gain.

However, there are some potential side-effects and risks. For example, it could increase the risk of ketoacidosis, pancreatitis, or bone fractures in people who have type 1 diabetes or in people over 65.

So what are you waiting for? Find out more about semaglutide injection today!

This information from Lexicomp ® tells you what you need to know about this drug, including its use, how to take it, its side effects, and when to call your health care provider.

Trade Names: US

Ozempic (0.25 or 0.5 MG/DOSE); Ozempic (1MG/DOSE); Rybelsus; Wegovy

Trade Names: Canada

Ozempic (0.25 or 0.5 MG/DOSE); Ozempic (1MG/DOSE); Rybelsus


  • This drug has been shown to cause thyroid cancer in some animals. It is not known also happens in humans. If thyroid cancer does occur, it can be fatal if not found and treated early. Call your doctor if you have a lump in your neck, trouble breathing, trouble swallowing, or hoarseness that does not go away.
  • Do not use this medicine if you have a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) or if you or a member of your family has cancer of the thyroid glands.

What is this medicine used for?

Ozempic prefilled pens and Rybelsus tablets:

  • This medicine is used to lower the blood sugar level in diabetic patients.

Ozempic prefilled pens:

  • they are consumed to lower the risk of heart attack, stroke, and death in some people.

Wegovy Prefilled Pens:

  • It is used to help lose weight in certain people.

What do I need to tell my doctor BEFORE taking this medicine?

For all uses of this medicine:

  • Suppose you are allergic to this drug, any component of this drug, or other drugs, foods, or substances. Tell your doctor about this allergy and what symptoms you have experienced.
  • If you have ever had pancreatitis
  • If you have or have had depression or suicidal thoughts.
  • If you are taking another medication with the same drug in its composition
  • Suppose you use another drug like this. If you are not sure, ask your doctor or pharmacist.

If used for high blood sugar:

  • If you have type 1 diabetes. Do not use this medicine to treat type 1 diabetes.

It is not a list of all drugs or conditions that may interact with this drug.

Tell your doctor and pharmacist about all medications you take (prescription, over-the-counter, natural products, vitamins) and your conditions. You should check that it is safe to take this medication with all your other medications and conditions. Do not start, stop, or change the dose of any medicine without first talking to your doctor.

What should I know or do while taking this medicine?

For all uses of this medicine:

  • Tell all of your health care providers that you take this medicine. It includes doctors, nurses, pharmacists, and dentists.
  • Follow the meal plan and exercise program as recommended by your doctor.
  • Check blood function as directed by your doctor. Consult the doctor.
  • Consult your doctor before drinking alcohol.
  • Kidney problems have occurred. Sometimes kidney problems should be treated in a hospital or by dialysis.
  • If you can’t drink liquids by mouth or have an upset stomach, vomiting, or diarrhoea that won’t go away, you’ll need to avoid becoming dehydrated. Contact your doctor for instructions. Dehydration can cause new or worse liver problems.
  • Do not share pens or cartridge devices with other people even if the needle has been changed. It is possible to spread infections from one person to another by sharing these devices. It includes conditions that you may not know you have.
  • If you intend to become pregnant, consult your doctor. You may need to stop taking this medicine at least two months before getting pregnant.

If used for high blood sugar:

  • Wear a medical alert ID for the disease.
  • Monitor your blood sugar as directed by your doctor.
  • Do not drive if your blood sugar has been low. There is a higher risk of an accident.
  • Your blood sugar level may be more challenging to control during times of stress such as fever, infection, injury, or surgery. A change in physical activity, exercise, or diet can also affect your blood sugar level.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You will need to talk about the risks and benefits to you and the baby.

If you use it for weight loss:

  • If you have diabetes, carefully monitor your blood sugar level.
  • Weight loss during pregnancy can cause harm to the unborn baby. If you get pregnant while taking this medicine or if you want to get pregnant, call your doctor right away.
  • Tell your doctor if you are breastfeeding your baby. You will need to talk about whether there are any risks to the baby.

What are the side effects I should call my doctor right away?

WARNING/CAUTION: Although very rare, some people may experience severe side effects, even death, from medication. If you experience any of the following signs or symptoms that may be related to a powerful side effect, tell your doctor or get medical help right away:

For all uses of this medicine:

  • Signs of allergic reaction such as rash; urticaria; itch; red, swollen, blistering, or peeling skin, with or without fever; wheezing; chest or throat tightness; trouble breathing, swallowing, or speaking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signos de problemas renales como la incapacidad de orinar, cambios en la cantidad de orina, sangre en la orina o un aumento de peso importante.
  • Síntomas de cálculos biliares como dolor repentino en el área abdominal superior derecha, el área del hombro derecho o entre los omóplatos, color amarillento en la piel o los ojos o fiebre con escalofríos.
  • Mareos severos o desmayos.
  • Latido cardíaco acelerado.
  • Cambio en la vista.
  • Low blood sugar can occur. The risk may be higher if you take this drug and some diabetes medications. The signs may be dizziness, headache, drowsiness, weakness, tremors, fast heartbeat, confusion, hunger, or sweating. Call your doctor right away if you have any of these signs. Follow the instructions you have been given if you have low blood sugar. It includes taking glucose tablets, liquid glucose, or some fruit juices.
  • Severe and sometimes fatal pancreatic problems (pancreatitis) have happened with this drug. Call your doctor right away if you have severe stomach pain, back pain, upset stomach, or vomiting.

If you use it for weight loss:

  • New or worse behaviour or mood changes, such as depression or suicidal thoughts.

What other side effects does this medicine have?

All medications can have side effects. However, many people have no side effects or only minor side effects. Call your doctor or seek medical help if any of these side effects bother you or do not go away:

If used for high blood sugar:

  • Constipation, diarrhoea, stomach pain or upset, or vomiting.


  • No appetite.

If you use it for weight loss:

  • Constipation, diarrhoea, stomach pain or upset, or vomiting.
  • Headache.
  • You feel dizzy, tired, or weak.
  • Belching.
  • Gas.

These are not all the side effects that could occur. If you have questions about side effects, call your doctor. Call your doctor for advice about side effects.

You can report side effects to the health agency in your country.

You can report side effects to the FDA at 1-800-332-1088. You can also report side effects at

Semaglutide Injection: What You Need to Know 2023

How is this medication best taken?

Take this medication as directed by your doctor. Read all the information given to you. Follow all instructions carefully.


  • Take about 30 minutes before your first food, drink, or medicine of the day.
  • Give this medication with water only. Do not take with more than 4 ounces (120 mL) of water.
  • It must be swallowed whole. It should not be chewed, broken or crushed.
  • Keep taking this medication as directed by your doctor or other health care provider, even if you feel fine.

Prefilled syringes or pens:

  • This medicine is injected into the fatty part of the skin, upper thigh, abdominal area, or upper arm.
  • If you are injecting yourself, your doctor or nurse will tell you how to give the injection.
  • Take this medicine with or without food.
  • Take it on the same day every week.
  • Change the injection site with each injection.
  • If the solution appears cloudy, leaking, or contains particles, do not use it.
  • Do not use it if the solution changes colour.
  • Wash your hands before and after use.
  • Keep taking this medication as directed by your doctor or other health care provider, even if you feel fine.
  • Dispose of needles in the sharps and needles box. Do not reuse needles or other supplies. When the container is full, follow all local procedures for disposal. If you have questions, ask your doctor or pharmacist.

If used for high blood sugar:

  • Before each dose, insert a new needle.
  • Remove the hand after each injection. Do not store this device with the arrow attached.
  • Recap after taking an amount.
  • If you also use insulin, you can inject this medicine and the insulin in the same body area but not next to each other.
  • Do not mix this medication in the same syringe as insulin.

If you use it for weight loss:

  • Each container is used only once. Use immediately after opening. Throw away any part of the opened container after applying the dose.

What should I do if I miss a dose?


  • Skip the missed dose and go back to your regular schedule.
  • Do not take two doses at the same time or take additional amounts.

Prefilled syringes or pens:

  • Take the missed dose as soon as possible and continue on your regular schedule.
  • If it is less than 48 hours until your next dose, skip the missed dose and continue with your regular schedule.
  • Do not take two doses within 48 hours of each other.
  • If you miss two doses, contact your healthcare provider.

How do I store or dispose of this medicine?


  • Store in its original container at room temperature.
  • Keep in a dry place. Do not store it in a bathroom.

Prefilled syringes or pens:

  • Store unopened syringes in the refrigerator. Do not freeze.
  • Do not use the product if frozen.

Ozempic prefilled pens:

  • After opening, store in the refrigerator or at room temperature. Throw away what you didn’t eat after 56 days.
  • Protect from heat and light.

Wegovy Prefilled Pens:

  • You can store unopened containers at room temperature. If stored at room temperature, discard unused portions after 28 days.
  • Store in the original container to protect from light.

All submissions:

  • Keep medicines in a safe place. Keep all medicine out of the reach of children and pets.
  • Throw away unused or expired medications. Do not flush them down the toilet or pour them down the drain unless instructed. Check with your pharmacist if you have questions about the best way to dispose of medications. There may be drug take-back programs in your area.

General information about the drug

  • If your symptoms or conditions do not improve or if they get worse, call your doctor.
  • Do not share your medication with other people or take anyone else’s medication.
  • Some medicines may have another patient information leaflet. If you have any questions about this medicine, talk to your doctor, nurse, pharmacist, or other health care provider.
  • This medication comes with an additional patient information sheet called a Medication Guide. Please read it carefully. Reread it each time you refill this medication. If you have any questions about this drug, talk to your doctor, pharmacist, or other health care provider.
  • Call your local poison control centre or seek medical attention immediately if you think an overdose has occurred. Be prepared to answer what was ingested, how much, and when.

Consumer Use of Information and Disclaimer

This general information is a little summary of a diagnosis, treatment, or medication. It is not intended to be exhaustive and should be used to help the user understand and evaluate possible diagnostic and treatment options. 

It does NOT include all information about diseases, treatments, medications, side effects, or risks that may apply to a specific patient. It is not intended to be medical advice or a substitute for a health care provider’s medical advice, diagnosis, or treatment based on the provider’s examination and evaluation of a patient’s specific and unique circumstances. 

Patients should speak with a health care provider for complete information about their health, medical questions and treatment options, including the risks or benefits related to the use of medications. 

This information does not recommend any treatment or drug as safe, effective, or approved for the treatment of any specific patient. UpToDate, Inc. and its affiliates disclaim any warranties or liability in connection with this information or its use. The Terms of Use available govern the use of this information.

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Semaglutide Injection: What You Need to Know 2023

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